By: Dr. Ashkan Jalili, DC, DACNB, FABBIR, FAAHP
Traumatic brain injury (TBI) remains a significant medical challenge, often leading to diverse and long-lasting impacts across all ages. A key aspect of TBI pathology is the disruption of normal brain processes, including glucose metabolism, which can lead to headaches, brain fog, memory loss, cognitive impairment and other dysfunctions associated with TBI. Unfortunately, most TBI treatments overlook the importance of glucose dysregulation and its pro-inflammatory response in the acute TBI (Koenig & Dulla, 2018) as well as post-TBI slow healing.
A specialized supplement formula combining antioxidants, amino acids, vitamins, minerals, phospholipids, herbal extracts, amino acids, and enzymes, is being considered for its potential in improving recovery outcomes and promise in addressing these issues. This article delves into the potential benefits of our new formula in TBI recovery (some of the ingredients only) and its unique role in normalizing brain glucose metabolism while suppressing the inflammatory cascade in the brain.
Antioxidants and Neuroprotection in TBI
S-Acetyl Glutathione and Alpha Lipoic Acid: These antioxidants reduce oxidative stress, crucial in mitigating brain injury. Kumar et al. (2015) highlighted glutathione's role in reducing oxidative damage. Alpha Lipoic Acid is particularly important after a concussion, as the brain may struggle with glucose uptake due to metabolic disruptions. Evans et al. (2002) discussed the role of Alpha Lipoic Acid in improving insulin sensitivity, which is crucial for effective glucose metabolism in the brain.
Co-Q 10: Improves mitochondrial function, essential in brain recovery (Matthews et al., 2009). CoQ10 is used largely to treat various neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Friedreich's ataxia and additional brain disease condition like autism, multiple sclerosis, epilepsy, depression, and bipolar disorder, which are related to mitochondrial impairment (Pradhan et al., 2021).
Curcomoid: These compounds play a crucial role in reducing inflammation via oxidative stress and improving mitochondrial function, essential in TBI recovery. Curcumin, a polyphenol found in Curcuma genus, has been shown to mitigate the pathophysiology and clinical sequalae involved in neuroinflammation and neurodegenerative diseases (Garodia et al., 2023).
Amino Acids and Neurotransmitter Precursors
L-Alpha-GPC, N-Acetyl L-Tyrosine, and L-Tryptophan: These serve as precursors for vital neurotransmitters, synaptic proteins aiding cognitive recovery post-TBI (Bémeur et al., 2010).
5-HTP and Taurine: These amino acids are vital for neurotransmitter synthesis and regulation, potentially aiding in mood stabilization and cognitive function in TBI patients via serotonergic pathway activation.
Herbal Extracts and Cognitive Function
Asian Ginseng, Rhodiola Extracts, Holy Basil: Enhance mental stamina and reduce fatigue (Panossian et al., 2010).
Lion’s Mane: Supports nerve regeneration, potentially aiding TBI recovery (Wong et al., 2012).
Berberine HCL: Known for its anti-inflammatory properties, it may have neuroprotective effects in brain injury (Zhang et al., 2012).
Vitamins, Minerals, and Brain Health
Magnesium Complex, B-Vitamins, Vitamin C, Niacin: Essential for neurological function and repair. Magnesium L-Threonate, in particular, is crucial for cognitive enhancement (Sun et al., 2016; Reynolds, 2006).
Unique Role in Glucose Metabolism
Chromium: Chromium plays a vital role in enhancing insulin sensitivity. Insulin is essential for the transport of glucose into brain cells. After a concussion, the brain's demand for glucose increases to support healing and regain normal function. By improving insulin sensitivity, chromium ensures more efficient glucose uptake by the brain, potentially aiding in the recovery process. This effect was noted in a study by Vincent (2000) which highlighted chromium's role in brain glucose metabolism and its potential in improving cognitive functions after TBI.
B-Vitamins, including Thiamine: Critical for energy metabolism, particularly glucose metabolism in the brain (Butterworth, 1993).
L-Carnitine: Affects glucose metabolism and enhances brain energy production, vital in TBI recovery (Virmani et al., 2002).
Phospholipids and Cognitive Enhancement
Phosphatidyl Serine: Essential for brain cell membrane integrity, phosphatidyl serine plays a crucial role in maintaining cognitive function and has been suggested to aid in recovery post-TBI (Glade MJ, Smith K, 2015).
Alpha-GPC: A phospholipid that acts as a choline source, enhancing cognitive function and aiding in the repair of brain cells post-injury (De Jesus Moreno Moreno M, 2003) (Lee et al., 2017).
Sage Extracts (Sibelius): Known for their cognitive-enhancing properties, sage extracts may improve memory and attention, which are often compromised in TBI (Kennedy DO et al., 2006).
Ginkgo Biloba Extracts: These extracts have been studied for their neuroprotective effects and potential to improve cognitive function and cerebral blood flow post-TBI (Rapin JR et al., 1994) (Singh et al., 2019).
St. John’s Wort: Traditionally used for mood disorders, this herb may have a role in managing the emotional and psychological effects post-TBI (Linde K et al., 2008).
Nootropics and Cognitive Enhancers
Vinpocetine: Enhances cerebral blood flow and metabolism, potentially improving cognitive function and neuroprotection in TBI patients (Bagoly et al., 2007).
Huperzine A: Known for its neuroprotective properties, it may enhance memory and cognitive functions, which are critical in TBI recovery (Zhang et al., 2008).
Overview
This unique supplement formulation offers a multi-targeted approach to support brain health in TBI patients. It not only addresses oxidative stress, neurotransmitter synthesis, and cognitive function but also uniquely targets the disrupted glucose metabolism in the brain—a very crucial aspect of TBI recovery. By combining elements that enhance insulin sensitivity, support energy metabolism, and provide necessary cofactors for enzymatic reactions, this formula could significantly improve outcomes in TBI management of patients with lingering brain fog, lethargy, mood swings, depression and anxiety. However, it's important to approach this treatment under medical guidance and consider individual patient needs. While each component shows promise, further research is necessary to fully understand their combined effects in TBI treatment.
Stay tuned for the release of the long-awaited TBI-Pro Recovery (AM and PM formula) in Vancouver! #TBIPRO
References
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• Reynolds, E. (2006). Journal of Neurology, Neurosurgery, and Psychiatry.
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• Garodia, P., Hegde, M., Kunnumakkara, A. B., & Aggarwal, B. B. (2023, Sep). Curcumin, inflammation, and neurological disorders: How are they linked? Integr Med Res, 12(3), 100968. https://doi.org/10.1016/j.imr.2023.100968
• Koenig, J. B., & Dulla, C. G. (2018). Dysregulated Glucose Metabolism as a Therapeutic Target to Reduce Post-traumatic Epilepsy. Front Cell Neurosci, 12, 350. https://doi.org/10.3389/fncel.2018.00350
• Lee, S. H., Choi, B. Y., Kim, J. H., Kho, A. R., Sohn, M., Song, H. K., Choi, H. C., & Suh, S. W. (2017, Jan 1). Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. Brain Res, 1654(Pt A), 66-76. https://doi.org/10.1016/j.brainres.2016.10.011
• Pradhan, N., Singh, C., & Singh, A. (2021, Nov). Coenzyme Q10 a mitochondrial restorer for various brain disorders. Naunyn Schmiedebergs Arch Pharmacol, 394(11), 2197-2222. https://doi.org/10.1007/s00210-021-02161-8
• Singh, S. K., Srivastav, S., Castellani, R. J., Plascencia-Villa, G., & Perry, G. (2019, Jul). Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders. Neurotherapeutics, 16(3), 666-674. https://doi.org/10.1007/s13311-019-00767-8
About the author:
With a professional journey that began in 2002 in Los Angeles, California, Dr. Ashkan Jalili is a respected Canadian chiropractor whose practice is deeply rooted in the principles of functional neurology, clinical neuroscience and metabolic medicine. His experience stretches from the vibrant community of Santa Monica to the dynamic cityscape of Vancouver, where he has been instrumental in introducing sophisticated neurological rehabilitation techniques.
Dr. Jalili's relocation to Vancouver in 2016 signified a commitment to advancing the field of clinical neuroscience in Canada. His practical approach combines the latest in neuroscience with a compassionate touch, offering hope and healing to patients with traumatic brain injuries and complex neurological disorders.
In his role as an Assistant Professor of Clinical Neurology at the Carrick Institute of Graduate Studies, Dr. Jalili imparts his considerable knowledge to the next generation of clinicians. His educational contributions have been felt through his involvement in Chiropractic Board Exam Reviews in the United States, where he has taught topics ranging from neurology to radiology.
Beyond his practice and teaching in North America, Dr. Jalili has also contributed to the international chiropractic community, serving as part-time faculty at Cleveland Chiropractic College in Los Angeles, and sharing his expertise with students at the Japan Chiropractic College in Tokyo.
Holding esteemed credentials such as a fellowship with the American Academy of Anti-Aging Regenerative Medicine, a Fellowship in the American College of Functional Neurology, and a Diplomate of the American Board of Chiropractic Neurology, Dr. Jalili is well-versed in the latest developments in his field. He also holds a Fellowship from the American Academy of Brain Injury and Rehabilitation, reflecting his dedication to the most current therapeutic approaches.
Dr. Jalili's professional ethos is centered on the careful application of functional neurology to enhance patient outcomes. His tailored metabolic therapies for individuals affected by neurological conditions reflect his dedication to both the science and the personal aspects of patient care. In the clinic and the classroom, Dr. Jalili is recognized for his thoughtful, measured approach to neurorehabilitation, making him a trusted figure among colleagues and patients alike.